CBG: The Mother Molecule

February 07, 2020

CBG: The Mother Molecule

CBG: The Mother Molecule

We hope that you’re already familiar with CBD (but if not, check out our info page!).  You may have also seen some of the other “CBs” around as well, like CBC, CBN, and CBG.  What are they, and what do they do? It’s high time we introduce you to other miraculous compounds found in cannabis, more importantly on the hemp side of cannabis! This time we’re going to give you the rundown on CBG.

What is CBG?

Cannabigerol, or CBG, is like the icy glacier from which two great rivers spawn.  It acts as a precursor to its end products - cannabidiol (CBD) and tetrahydrocannabinol (THC).  Both are branches of the same tree which is CBG [1].

CBG is a naturally-occurring compound found in cannabis plants.  As the cannabis plant matures and begins to flower, more and more of the CBG present undergoes transition into either THC or CBD.  

How does CBG make you feel?

Like it’s descendant cannabidiol, CBG is non-intoxicating, so you shouldn’t expect the psychoactive effects of THC when using it.  In fact, because of the way that CBG interacts with your body’s endocannabinoid system (ECS), it has the opposite effect and can actually counter balance the high from THC [1].


For some consumers, using THC tends to draw them inside themselves and increase their anxiety.  CBG can also help here because it can counteract the increased anxiousness from THC with its own anti-anxiety properties.

CBG isn’t intoxicating as THC is, but it can certainly still provide benefits that improve your mood and has been shown to offer relief from anxiety and depression [2].  

CBG is best when used with CBD in a broad spectrum or full spectrum cannabis product which contains all the compounds found in cannabis as opposed to an isolate (CBD by itself).  When used together, they have a synergistic interaction known as the “entourage effect” which increases the benefits and allows CBG to play its role to its fullest.

What other benefits are available from CBG?

Like CBD, cannabigerol is a cannabinoid known for its healing benefits and has shown promise in the following areas:

  • Eye conditions - CBG reduces intraocular pressure, and could be a great candidate for glaucoma therapy. [3].
  • Neurodegenerative disease -   with its ability to protect from nerve degeneration, Parkinson’s and Huntington’s patients may benefit from CBG [4].
  • Potential cancer-fighter -  CBG has been demonstrated to target and reduce cancer cell growth and migration, and has been recommended in conjunction with chemotherapy [5].
  • Skin inflammation - unique properties of CBG when compared to CBD or THC allow it to be extra effective for ailments ranging from dry skin and rash conditions to skin cancer [6].
  • Antibacterial - CBG plays a role in inhibiting growth of antibiotic-resistant bacteria like MRSA, which could be a game-changer in medicine [7].
  • Bowel disease - studies have suggested that CBG may have value for those suffering from IBD/IBS and colitis. Its antiinflammatory properties greatly improved the symptoms for test subjects (mice) and should be experimented further [8].

How much does CBG cost?

Because most strains of cannabis today are bred for producing as much CBD or THC as possible, it’s very difficult to get CBG in high amounts.  We do expect strains to develop in future that are higher in CBG at maturity than they are today. For now however, to extract CBG in significant amounts for isolate, the plants must be harvested before their full maturity.  

For a plant with an eight-week flowering cycle, this means crops grown to maximize their CBG content are harvested closer to six [9], before the CBG has been converted en masse to CBD and/or THC.

Because the plant is much smaller at harvest, up to 20 times as much biomass must actually be used to extract CBG as CBD from fully grown cannabis [9], which can also make CBG much more expensive compared to the same amount of CBD.

Products with high amounts of CBG on Modest Hemp Co.

We have one particular lineup that we feel is especially formulated towards this product type; and that's Hyve CBD. Their incredible, three flavored, CBD tincture line has increased levels of CBG; which has been designed to help assist with all of the ailments you have read about above! Their product holds high amounts of CBG at a great price point! Get ready for some rest and relaxation! 

The Modest Box features three fantastic broad and full-spectrum products so you can get the benefits of CBG for one low price as well! Lastly, our most recent Modest Box curates Hyve CBD to highlight them joining our Modest Family! 

I hope you’ve gained a deeper understanding of what CBG is, how it interacts with your body, and its benefits.  Have other questions? Please write to us from the Contact Us page, or comment below. We’d love to hear from you!


-S. Mills


[1] Nunley, Kim. “CBG - The Parent of Both CBD and THC.” Medical Marijuana, Inc., Medical Marijuana, Inc., 15 Aug. 2019, https://www.medicalmarijuanainc.com/cbg-parent-cbd-thc/. 
[2] Skrobin, Nicole. “What You Need to Know about the Healing Benefits of Marijuana's CBG.” The GrowthOp, Postmedia Network Inc., 20 Feb. 2019, https://www.thegrowthop.com/cannabis-health/what-you-need-to-know-about-the-healing-benefits-of-marijuanas-cbg.
[3] Colasanti, Brenda K., et al. “A Comparison of the Ocular and Central Effects of Δ9-Tetrahydrocannabinol and Cannabigerol.” Mary Ann Liebert, Inc., Publishers, Mary Ann Liebert, Inc., 18 Mar. 2009, https://www.liebertpub.com/doi/abs/10.1089/jop.1990.6.259.
[4] Emerald Health Pharmaceuticals. “Emerald Health Pharmaceuticals Demonstrates Neuroprotective Activity of Novel Cannabigerol Derivatives in Huntington's and Parkinson's Disease Models.” GlobeNewswire News Room, GlobeNewswire, Inc., 2 July 2019, https://www.globenewswire.com/news-release/2019/07/02/1877328/0/en/Emerald-Health-Pharmaceuticals-Demonstrates-Neuroprotective-Activity-of-Novel-Cannabigerol-Derivatives-in-Huntington-s-and-Parkinson-s-Disease-Models.html.
[5] Chakravarti, Bandana, et al. “Cannabinoids as Therapeutic Agents in Cancer: Current Status and Future Implications.” Oncotarget, Impact Journals LLC, 15 Aug. 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171598/.
[6] Demski, Nicholas. “CBG May Help Improve People's Skin Health Better Than THC or CBD.” Journal of Cannabinoid Medicine, Cannabinoid Medical Journal, 12 June 2019, https://journalofcannabinoidmedicine.com/cbg-may-help-improve-peoples-skin-health-better-than-thc-or-cbd/.
[7] Appendino, Giovanni, et al. “Antibacterial Cannabinoids from Cannabis Sativa: a Structure-Activity Study.” Journal of Natural Products, U.S. National Library of Medicine, 7 Aug. 2008, https://www.ncbi.nlm.nih.gov/pubmed/18681481.
[8] Borrelli, Francesca, et al. “Beneficial Effect of the Non-Psychotropic Plant Cannabinoid Cannabigerol on Experimental Inflammatory Bowel Disease.” Biochemical Pharmacology, Elsevier B.V., 12 Feb. 2013, https://www.sciencedirect.com/science/article/abs/pii/S0006295213000543.
[9] Reynolds, James, and Joe Martinez. “Cannabigerol CBG: The Main Precursor to All Cannabinoids.” Alchimia Blog, Alchimiaweb S.L., 15 May 2018, https://www.alchimiaweb.com/blogen/cannabigerol-cbg/.
[10] Lassalle, Janelle. “Why CBG (Cannabigerol) Is One Of The Most Expensive Cannabinoids To Produce.” Forbes, Forbes Media LLC., 11 Sept. 2019, https://www.forbes.com/sites/janellelassalle/2019/09/11/why-cbg-cannabigerol-expensive-produce/#d7201262f771.